A comparative analysis of different biofluids using Raman spectroscopy to determine disease activity in ANCA ‐associated vasculitis
نویسندگان
چکیده
Identifying persistent or relapsing disease in anti-neutrophil cytoplasmic autoantibody- associated vasculitis (AAV) remains a clinical challenge with an unmet need for reliable biomarker of multisystem disease. In this study, we confirm the first time that Raman spectroscopy offers novel cost-effective candidate to discriminate active from remission AAV excellent accuracy. Spectrochemical interrogation plasma and serum samples demonstrated equal ability activity good group separation on PC1 direction high degree accuracy validation testing using blind predictive modelling: F-score 80% (specificity 93.3%, sensitivity 70%, AUC 0.95) 80%, 0.92). Similar findings were seen analysis paired following successful remission-induction therapy. A larger study longitudinal data is required validate these potential aid patient care.
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ژورنال
عنوان ژورنال: Journal of Biophotonics
سال: 2021
ISSN: ['1864-0648', '1864-063X']
DOI: https://doi.org/10.1002/jbio.202000426